KMID : 1200020150390010001
|
|
Diabetes & Metabolism Journal 2015 Volume.39 No. 1 p.1 ~ p.9
|
|
Pancreatic ¥á-Cell Dysfunction in Type 2 Diabetes: Old Kids on the Block
|
|
Moon Jun-Sung
Won Kyu-Chang
|
|
Abstract
|
|
|
Type 2 diabetes (T2D) has been known as ¡¯bi-hormonal disorder¡¯ since decades ago, the role of glucagon from ¥á-cell has languished whereas ¥â-cell taking center stage. Recently, numerous findings indicate that the defects of glucagon secretion get involve with development and exacerbation of hyperglycemia in T2D. Aberrant ¥á-cell responses exhibit both fasting and postprandial states: hyperglucagonemia contributes to fasting hyperglycemia caused by inappropriate hepatic glucose production, and to postprandial hyperglycemia owing to blunted ¥á-cell suppression. During hypoglycemia, insufficient counter-regulation response is also observed in advanced T2D. Though many debates still remained for exact mechanisms behind the dysregulation of ¥á-cell in T2D, it is clear that the blockade of glucagon receptor or suppression of glucagon secretion from ¥á-cell would be novel therapeutic targets for control of hyperglycemia. Whereas there have not been remarkable advances in developing new class of drugs, currently available glucagon-like peptide-1 and dipeptidyl peptidase-IV inhibitors could be options for treatment of hyperglucagonemia. In this review, we focus on ¥á-cell dysfunction and therapeutic potentials of targeting ¥á-cell in T2D.
|
|
KEYWORD
|
|
Diabetes mellitus, type 2, Glucagon, Glucagon-secreting cells, Insulin, Insulin-secreting cells
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|